Azopt 1% (brinzolamide ophthalmic suspension)is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion and thus lowers the intraocular pressure in the anterior chamber, presumably by reducing the rate of formation of bicarbonate ions with subsequent reduction in sodium and fluid transport.
The recommended dose is one drop of Azopt 1% in the affected eye(s) three times daily. Before using the medication, the bottle should be shaken. Do not touch the eye with the tip of the dropper bottle. Remove contact lenses prior to applying the medication and wait at least 15 minutes after application to put contact lenses back on. Tasks that require attention and focus, such as driving and operating machinery, should be performed with great caution.
Patients with severe hepatic dysfunction have to take Azopt with extra caution as its metabolites are excreted in the urine. It should be borne in mind that with the development of serious adverse reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, hepatonecrosis, agranulocytosis, aplastic anemia) patient should stop taking this drug.
Azopt 1% is contraindicated in patients who are hypersensitive to any component of this product. Pregnant women have to use Azopt carefully and only if there is no risk to harm fetus.
Possible side effect
Headache, dizziness, foreign body sensation, itching of the eyes, blurred vision, blepharitis, keratitis, dermatitis, dry eyes and hyperemia. Side effects may also occur in a digestive system (a bitter, sour taste in the mouth, dyspepsia, nausea,diarrhea). It may aslo affect cardiovascular system (chest pain, hypertension) and hematopoietic system (agranulocytosis, aplastic anemia).
Azopt 1% may be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure. If more than one topical ophthalmic drug is being used, the drugs should be administered at least ten (15) minutes apart.Please note that it is better not to use Asopt with drugs related to inhibitors of carbonic anhydrase (Glaupax, Nephramid, etc.)as there is a high probability to increase the side effects of the drops.
In case you have missed to take the prescribed dose of this drug, take it as soon as possible. If you are already supposed to take your next dose, do not take the dose you forgot and keep your ordinary dosage schedule. Avoid compensating a missed dose by taking an extra one.
Development of an acidoric state, electrolyte imbalance and possible nervous system effects may occur following an oral admisitration of an overdose. Blood pH levels and serum electrolyte levels should be monitored.
This medicine is stored unopened in the refrigerator. If the medicine is opened, it should be kept at room temperature for 6 weeks away from light, heat, moisture. Avoid storing the drug in the bathroom. Keep all drugs away from reach of children and pets. Do not use in case the expiry date is over.
The information presented at the site has a general character. Note please this information cannot be used for self-treatment and self diagnosis. You should consult with your doctor or health care adviser regarding any specific instructions of your condition. The information is reliable, but we concede it could contain mistakes. We are not responsible for any direct, indirect, special or other damage caused by use of this information on the site and also for consequences of self-treatment.
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